Nunes, Kenia

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副教授 | 生物医学工程与科学

Program Chair |生物医学

knunes@mtzhjy.com
(321) 674-7134
F.W. 生命科学，2014

ORCID
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Research Website

个人概述

我是一名研究糖尿病等疾病的血管生物学家, hypertension, 和勃起功能障碍(ED). I received my master’s degree in Molecular and Biochemistry Pharmacology and my Ph.D. in Human Physiology from the Federal University of Minas Gerais, Brazil. My work includes research and two patents on using a spider toxin (PnTx2-6) to treat ED. This research project has been performed in collaboration with scientists in Brazil. In 2009, as a postdoctoral fellow at 奥古斯塔大学 (former 乔治亚医学院), I studied how the innate immune system contributes to vascular dysfunction in chronic diseases such as hypertension and diabetes. In 2015 I joined Florida Tech and started the Vascular Biology lab. Currently, my lab research is focused on molecules such as HSP70 and TLR4 as pharmacological targets to mitigate vascular problems.

教育背景

Post-doc. Vascular Biology - 乔治亚医学院 - 奥古斯塔大学, USA

Ph.D. 生理学-米纳斯吉拉斯州联邦大学-巴西

M.Sc. Biomedical & Molecular Pharmacology - Federal University of Minas Gerais - Brazil

B.S. 生物学-米纳斯吉拉斯州联邦大学-巴西

专业经验

2021-现任:生物医学部副教授 & 化学工程 & Sciences
07/2015- 2020: Assistant Professor, Department of Biological Sciences, College of Sciences, FIT
2013.06 - 2015.06:副研究员, 细胞与再生生物学系, 医学和公共卫生学院, 威斯康星大学;
2012.06 -2013，助理研究员, 奥古斯塔大学, 乔治亚医学院, 生理学系;
2009.02 -2012:博士后, 奥古斯塔大学, 乔治亚医学院, 生理学系,
2004 / 02 -2008:生理学助理教授, 大学校长安东尼奥·卡洛斯, Nursing School, 位于Conselheiro Lafaiete的校园, Minas Gerais, Brazil.

Current Courses

人体解剖学与生理学1 & II

应用生理学

科学技能-血管功能和功能障碍

心血管机制和途径

生物研究

选定的出版物

Publications in the past four years out of 51 total peer-reviewed manuscripts.

2022

Increased eHSP70-to-iHSP70 ratio disrupts vascular responses to calcium and activates the TLR4-MD2 complex in type 1 diabetes. de Oliveira AA*， Priviero F, Webb RC， Nunes KP. Life Sciences; 310:121079, 2022. DOI: 10.1016/j.lfs.2022.121079

Drugs from animal venoms: Overcoming the challenges to treat erectile dysfunction. De Lima ME, Nunes KP. 毒液和毒素; vol 2, issue 2, 2022. DOI: 10.2174/2666121702666220425111433

Connecting aortic stiffness to vascular contraction: Does sex matter? de Oliveira AA*， Priviero F, Delgado A*，彭飞D，门多萨VO*，顾磊，Webb RC， Nunes KP. 国际分子科学杂志; 23(19):11314, 2022. DOI: 10.3390 / ijms23191131.

New insights into the role and therapeutic potential of HSP70 in diabetes. de Oliveira AA*, Mendoza VO*, Rastogi S*, Nunes KP. 药理研究, 178:106173, 2022. DOI: 10.1016/j.phrs.2022.106173

Age-related decline in vascular responses to phenylephrine is associated with reduced levels of HSP70. de Oliveira AA*， Mendoza VO, Priviero F, Webb RC， Nunes KP. Biomolecules; 12(8):1125, 2022. DOI: 10.3390 / biom12081125

这篇原创文章入选“编辑之选”.

From the PnTx2-6 toxin to the PnPP-19 Engineered Peptide: Therapeutic Potential in Erectile Dysfunction, Nociception, and Glaucoma. da Silva CN, Nunes KP, Dourado LFN, Vieira TO, Mariano XM, Cunha Junior ADS, de Lima ME. Front Mol Biosci,11;9:831823, 2022. DOI: 10.3389/fmolb.2022.831823

2021

Impaired HSP70 expression in the aorta of female rats: a novel insight into sex-specific differences in vascular function. de Oliveira AA*， Priviero F, Webb RC， Nunes KP. 生理学前沿， 12:517, 2021. DOI: 10.3389/fphys.2021.666696

COVID-19和ROS风暴:高血压的预测是什么. de Oliveira AA, Priviero F, Lima VV, Webb RC， Nunes KP. 中华高血压病杂志，9;34(8):779-782。 2021. DOI: 10.1093 / ajh / hpab085.

The synthetic peptide PnPP-19 potentiates erectile function via nNOS- and iNOS. CN da Silva, KP Nunes, FM Almeida, GC Silva, PS Cunha, TF Diniz, LM Maia, VS Lemos; DA Gomes, ME de Lima. Nitric Oxide, 113-114: 23-30, 2021. DOI: doi.org/10.1016/j.niox.2021.04.007

New insights into RhoA/Rho-kinase signaling: a key regulator of vascular contraction. Nunes KP, Webb RC. Small GTPases. 12(5-6):458-469, 2021. DOI: 10.1080/21541248.2020.1822721

TLR4的串扰, 血管NADPH氧化酶, 和COVID-19在糖尿病中的潜在影响是什么? de Oliveira AA* & Nunes KP. 心血管药理学; 26:106879, 2021. DOI: 10.1016/j.vph.2021.106879

《亚洲博彩平台》强调了这一专题审查.

2020

Dissecting the interaction between HSP70 and vascular contraction: role of Ca2+ handling mechanisms. de Oliveira AA, Priviero F, Tostes R, Webb RC， Nunes K. 科学报告, 11:1420, 2020. DOI: 10.1038/s41598-021-80966-6

Hypertension and erectile dysfunction: breaking down the challenges. de Oliveira AA*, Nunes KP. 美国高血压杂志. 34(2):134-142, 2020. DOI: 10.1093/ajh/hpaa143

这篇文章是应博士的邀请而写的. 埃内斯托·希夫林，AJH的主编.

Blockade of TLR4-MD2 complex lowers blood pressure and improves vascular function in a murine model of type 1 diabetes. AA de Oliveira*, J Faustino*, RC Webb, KP Nunes. 科学报告 10, 12032, 2020. DOI: 10.1038/s41598-020-68919-x

An additional physiological role for HSP70: Assistance of vascular reactivity. AA de Oliveira* & KP Nunes. Life Sciences, 117986, 2020. DOI: 10.1016/j.lfs.2020.117986

Angiotensin (1-7) Inhibits Ang II-mediated ERK1/2 Activation by Stimulating MKP-1 Activation in Vascular Smooth Muscle Cells. A Sousa-Lopes, R Alves de Freitas, FS Carneiro， KP Nunes, et al. International 分子与细胞医学杂志 (jmc)， 9 (1)， 50-61; 2020. DOI: 10.22088/IJMCM.BUMS.9.1.50

Blockade of Toll-like receptor 4 (TLR4) reduces oxidative stress and restores phospho-ERK1/2 levels in Leydig cells exposed to high glucose. T KarpovaAA·德·奥利维拉*, H Naas*, F Priviero, KP Nunes. Life Sciences, 117365, 2020. DOI: 10.1016/j.lfs.2020.117365

2019

Toll-like receptor 4 (TLR4) as a possible pathological mechanism in hyperglycemia-associated testicular dysfunction. H Naas*AA·德·奥利维拉*, T Karpova, KP Nunes. 医学假说, 127, 116-119, 2019. DOI: 10.1016/j.mehy.2019.04.010

Toll-like receptor 4 and blood pressure: Lessons from animal studies. KP NunesAA·德·奥利维拉*VV利马，RC韦伯. 生理学前沿, 655, 2019. DOI: 10.3389/fphys.2019.00655

Unveiling the interplay between the TLR4/MD2 complex and HSP70 in the human cardiovascular system: a computational approach. AA de Oliveira*， J·福斯蒂诺*，m·德·利马，R·梅内塞斯， KP Nunes. 国际分子科学杂志， 20 (13), 3121, 2019. DOI: 10.3390 / ijms20133121

PnPP-19 Peptide Restores Erectile Function in Hypertensive and Diabetic Animals Through Intravenous and Topical Administration. CN da Silva, KP Nunes, FDM Almeida, FLS Costa, PV Borges, P Lacativa等. 性医学杂志， 16 (3), 365-374, 2019. DOI: 10.1016/j.jsxm.2019.01.004

Pattern recognition receptors as potential therapeutic targets in metabolic syndrome: From bench to bedside. AA de Oliveira*, D Davis*, KP Nunes. Diabetes & 代谢综合征:临床研究 & Reviews, 13 (2), 1117-1122., 2019. DOI: 10.1016/j.dsx.2019.01.012

精选书籍章节:

De Lima ME, Figueiredo SG, Matavel A， Nunes KP, da Silva NC, Almeida FM, Diniz MRV, Cordeiro MN, Stankiewicz M and Beirao PSL.(2015). 黑耳鼠毒液及毒素研究进展. 在:蜘蛛毒液. 由施普林格科学编辑. DOI: 10.1007/978-94-007-6646-4_6_1
Kenia P. Nunes and R. Clinton Webb. (2011) Mechanisms in Erectile Function and Dysfunction: An Overview. In: Erectile Dysfunction - Disease-Associated Mechanisms and Novel Insights into Therapy. 第一章，由In Tech Book编辑. DOI: 10.5772/39088
Nunes KP, Cardoso, F.L., Cardoso Jr, H.C., Pimenta, A.M.C., De Lima, M.E. (2009) Animal toxins as potential pharmacological tools for the treatment of erectile dysfunction. In: Animal toxins: State of the art Perspectives in health and biotechnology, vol. 1 (De Lima, M. E., Pimenta, A.M.C.马丁·欧克莱，M.F., Zingali, R. and Rochat, H.，编)，314-322页贝洛奥里藏特:UFMG编辑.

Recognition & Awards

Ongoing award:

2022- 2025, National Institute of Health- NIDDK- Title: Dual role of HSP70 in diabetes-associated vascular dysfunction ($ 486.000,00).

Past awards:

2018-2019，佛罗里达空间研究计划(NASA). Title: The interplay between cardiovascular disease and space radiation. ($ 50,000.00)
2012- DEZ/2016, Scientific Development Grant (National)- American Heart Association - Title: Toll-like receptor 4 (TLR4) plays an important role in hypertension. ($ 300.000,00)
2009-2011, Fellowship from American Heart Association (Southeast Affiliate) – Post-Doctoral Fellow
($70.00,00)